molecular identification of human papiloma virus (hpv) in cervical neoplasia and the risk factors affecting cervical cancer in isfahan

نویسندگان

nafise sadat naghavi

department of microbiology, falavarjan branch, islamic azad university, isfahan, iran.سازمان اصلی تایید شده: دانشگاه آزاد اسلامی فلاورجان (islamic azad university of felavarjan) b mazrouei

young researchers and elite club , falavarjan branch , islamic azad university , isfahan , iran.سازمان اصلی تایید شده: دانشگاه آزاد اسلامی فلاورجان (islamic azad university of felavarjan) m shanehsazzadeh

zistpartac research institute, isfahan, iran es naghavi

amin hospital, isfahan university of medical sciencesسازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (isfahan university of medical sciences)

چکیده

the rate of cervical cancer in asians is deferent, based on the risk factors affecting and the rate of papiloma virus infection among females. cervical cancer is one of the important cancers between iranian women. in the present study the rate of cervical neoplasia was detected in isfahan and some risk factors affecting the incidence of cervical cancer was analyzed. the human papiloma virus infection was also detected in cervical neoplasia via pcr method after dna extraction. 15000 pap smear tests results achieved from patient documents for detection of the rate of squamous cell neoplasia, based on at least one report in pap smear test in a random and distributed sampling. we have also studied the effect of some risk factors on the incidence of cervical cancer in 100 patient and 100 females without any neoplasia report as a control group. the results analyzed by chi2 and t tests. the rate of human papiloma virus (hpv) infection detected in pap smear specimens using specific primers for amplification of hpv genome. at least one neoplastic report was shown in 0.91% of females and 0.61% of which had at least one ascus report. 55.4% of patients with neoplasic pap tests were infected with hpv in pcr test. teenage marriage, high parities, lower education and smoking increases the risk of cervical neoplasia. it is concluded that molecular methods including genome analysis are useful method in identification of hpv.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Molecular Identification of Human Papiloma Virus (HPV) in Cervical Neoplasia and the Risk Factors Affecting Cervical Cancer in Isfahan

The rate of cervical cancer in Asians is deferent, based on the risk factors affecting and the rate of papiloma virus infection among females. Cervical cancer is one of the important cancers between Iranian women. In the present study the rate of cervical neoplasia was detected in Isfahan and some risk factors affecting the incidence of cervical cancer was analyzed. The human papiloma virus inf...

متن کامل

the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region

چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...

15 صفحه اول

Study of Effective Factors in Cervical Cancer in Isfahan

ABSTRACT Cancer of the cervix is a common malignancy in females' genital tract. This is the third most common malignancy in females. The main object of this study was to determine the risk factors associated with cervical cancer. In this case-control study, from 282 cases, 87 patients with progressive disease were in the case group and 195 healthy women in the control group. Sampling method in...

متن کامل

Distribution of HPV Genotypes and Involvement of Risk Factors in Cervical Lesions and Invasive Cervical Cancer: A Study in an Indian Population

Human papilloma virus (HPV) is considered as the main sexually transmitted etiological agent for the cause and progression of preneoplastic cervical lesions to cervical cancer. This study is discussing the prevalence of HPV and its genotypes in cervical lesions and invasive cervical cancer tissues and their association with various risk factors in women from Varanasi and its adjoining areas in ...

متن کامل

Prevalence Of Human Papilloma Virus Among Women With Cervical Intraepithelial Neoplasia III And Invasive Cervical Cancer From 2001 To 2006 In Bandarabas

  Background and Objective: To estimate the risk of human papilloma virus (HPV) infection for cervical malignancies, we conducted a case-control study in southern Iran (Hormozgan province). Materials and Methods: For this purpose,52 paraffin embedded blocks with exact diagnosis of cervical carcinoma(50 carcinomas and 2 carcinomas in situ) from 2001 to 2006 and 52 praffin embedded blocks of ce...

متن کامل

Comparison of Molecular (PCR) and Pap Smear Methods in Diagnosis of Human Papiloma Virus (HPV) in Women with Genital Warts

Abstract Background and Objective: Much research has shown that Human Papiloma Virus (HPV) plays an important role in cervix cancer and it is the cause of 99% of cervix cancer worldwide. Lots of research has been done to find a proper method for HPV diagnosis and screening in patients with genital warts. This study aimed at comparing PCR method with Pap smear test in HPV screening. Materi...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
international journal of molecular and clinical microbiology

جلد ۲، شماره ۲، صفحات ۱۹۱-۱۹۳

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023